BCHM 218 Molecular Biology
Dr. Laura van Staalduinen, Dr. Doug Quilty
BCHM 218, Molecular Biology, is a foundational course to the study of molecular biology, focusing on the structural and functional properties and relationships of DNA, RNA and proteins, particularly the processes required to reliably pass genetic information from DNA to RNA to protein, and from one generation to the next. This course also examines how these processes are related to the development of human diseases and to basic biotechnology techniques and genetic engineering concepts that are critical for synthetic biological system creation and integration. This experience will arise through their involvement in the following four main elements of inquiry:
- Section 1: What are the properties and interactions of genetic information molecules?
- Section 2: How are genomes organized and protected, and how can they be studied?
- Section 3: How do organisms copy and edit genomes?
- Section 4: What are different ways that organisms regulate gene expression?
Each section will be accompanied by problem-based learning exercises (PBLs) where students can actively engage with the learning material. In addition, students will be able to assess their knowledge of each particular section through online quizzes. Students will use Molecular simulation and animation activities such as PyMol and Visual Synthesis Map in the online textbook BioPortal to model and mimic the behaviour of molecules to help them prepare for these exercises. Practice questions are available in the textbook and on the textbook website to assist students in preparing for quizzes and exams.
Minimum 2nd year (Level 2) standing and one of (BIOL102/3.0; PHGY 170/3.0) and one of (CHEM112/6.0; CHEM114/3.0).
Note: In class version also exists.
After completing BCHM 218, students will be able to:
- Explain how biomolecules (DNA, RNA, and protein) function and interact to support life;
- Apply research-based theories to solve problems related to biochemistry and molecular biology;
- Use computer-based multimedia to model and mimic the behaviour of biomolecules when conditions can be controlled in an in vitro-type experimental situation, and within the context of simulated cells
Assessment 1: Poll Everywhere Sessions (5%)
Assessment 2: End of Module Quizzes (4)(15%)
Assessment 3: Problem-Based Activities (4)(20%)
Assessment 4: Midterm Exam (on Modules 1 and 2)(30%)
Assessment 5: Final Exam (on Modules 3 and 4)(30%)
9–10 hours a week (108–120 hours per term).
Molecular Biology: Principles and Practice, 2nd edition + LaunchPad (BioPortal)