Queen's University
BCHM 270 Biochemical Basis of Health and Disease

BCHM 270, Biochemical Basis of Health and Disease, will introduce general biochemical concepts that will allow for an understanding of the biological and chemical principles underlying human physiology, health, and disease. The course will provide self-paced learning and utilize evidence-based teaching principles, small group learning, peer-learning, and guided-independent learning methodologies to provide an inclusive learning environment. Students will gain an enhanced appreciation of general applications of biochemistry as applied in day to day healthy life and during the disease states, diagnosis and clinical management of metabolic disorders.

Minimum 2nd year (Level 2) standing , 4U Biology recommended, and (PHGY 170/3.0) or (BIOL 102/3.0), or permission of the instructor.

For non-BHSc students

  • No more than 3.0 units from BCHM 102/3.0 and BCHM 270/3.0
  • May not be taken with or after BCHM 315/3.0 or BCHM 310/6.0

After completing BCHM 270, students will be able to:

  1. To apply an understanding of biochemical processes and their interactions to explain how the human body functions in health and disease.
  2. To collaborate to consolidate information about an important aspect of a biochemical pathway and communicate its importance to normal cellular function.
  3. To integrate biochemical concepts and their associated processes to explain the consequences of a perturbation in a particular biochemical process.
  1. Communicator
  2. Advocate
  3. Leader
  4. Scholar
  5. Professional
  6. Collaborator

All assessments will be graded using marking rubrics.

Assessment 1 – Pamphlet/Data Sheet Assignment (25%)

For this assignment, students will be assigned to small groups, and using information learned in the course modules, as well as some independently-researched sourced literature, students will be expected to design an informational data sheet on a particular protein or enzyme that is involved in a pertinent biochemical pathway. The audience that this data sheet will be aimed at is a medical professional. Students must work together to collect and organize data in a logical and informative fashion.  Students will submit a group report and will be required to evaluate themselves, as well as their peers, on their contributions to the assignment.

Assessment 2 – Case Study Analysis (33%)

For this assignment, students will be given a case study in which they need to problem solve. In TA-directed synchronous discussions, students will work together to determine the most rationale explanation for the case presented. Following the discussion, students will independently write and submit a summary of this case study discussion for grading. Students will need to assess themselves, as well as their peers, for contributions to this discussion.

Assessment 3 – Module Tests (x6) (42%)

Upon completing each module (a total of 6), students will complete module tests that require the student to apply knowledge learned in the course, as opposed to requiring rote memorization. Each module test will be cumulative, with the weighting of each test increasing throughout the semester (Test 1: 2%, Test 2: 4%, Test 3: 6%, Test 4: 8%, Test 5: 10%, Test 6: 12%).

10–11 hours a week (120–132 hours per term).

Required Texts

BCHM 270 course notes via modules posted online and select readings made available by the instructor.